6 June 2023
In vitro antiviral activity of hyperbranched poly-L-lysine modified by L-arginine against different SARS-CoV-2 variants. F. Fiori, F. L. Cossu, F. Salis, D. Carboni, L. Stagi, D. De Forni, B. Poddesu, L. Malfatti, A. Khalel, A. Salis, M. F. Casula, R. Anedda, F. Lori, P. Innocenzi. Nanomaterials, 2023, 13, 3090
The manuscript discusses the urgent need to monitor SARS-CoV-2 variants, particularly the rapidly spreading Omicron, while presenting research on L-arginine-modified hyperbranched poly-L-lysine nanopolymers, which effectively block viral replication of various SARS-CoV-2 strains and exhibit a twelve-fold increased therapeutic index, indicating their potential as broad-spectrum antivirals.